KCNG4 encodes for the voltage-gated potassium channel subunit Kv6.4. CIMR PhD student Iain Hay and colleagues from the labs of co-supervisors Janet Deane (CIMR) and Hayley Sharpe (Babraham), together with Maja Koehn (Freiburg) have published in Nature Communications on the structure and function of the receptor protein tyrosine phosphatase PTPRU. Final-year CIMR PhD student Alice Fletcher-Etherington in the Weekes lab, together with other colleagues have published in PNAS on how human cytomegalovirus (HCMV) can subvert host cell death pathways to enhance its cellular infectivity. He will focus on interactions between endoplasmic reticulum proteins and the functional organisation of a group of cytosolic partners.Congratulations to the CIMR’s Professor David Rubinsztein for his award of the Pathological Society’s Goudie Medal. However, the outbreak of World War I soon afterwards postponed occupation of the building, although senior staff were appointed … The unit collaborates closely with other groups in the.The MRC Integrative Epidemiology Unit at the University of Bristol (MRC IEU) seeks to integrate molecular, cellular, clinical and population data to optimise the identification of causal associations between potentially modifiable exposures and health outcomes.
MRC MHU research is closely integrated with the National Health Service, giving access to patients with haematological disease and clinical material, thus ensuring that the Unit’s scientific developments can be rapidly translated into improved clinical care. This process results in the downregulation of the NFκB and IRF3 pathways, inflammatory cytokine secretion, and therefore a reduced immune response. In response, the CIMR’s Prof. Randy Read has provided a follow-up critique in the same preprint repository which argues that from bioinformatic, thermodynamic and structural biology perspectives, the methods from the original article were fatally flawed (https://tinyurl.com/y9vm8feq). Their work will lead to more effective ways of preventing and treating all types of cancer in the future.We fund a network of state-of-the-art facilities at 90 institutions across the UK.
Using mass cytometry to simultaneously measure multiple signalling pathways during activation of murine CD8+ T cells, they found a programme of distal signalling events that is shared, regardless of the strength of TCR stimulation. Ultrastructural analysis of these foci reveals that this compartment consists of a tight cluster of small membrane vesicles, which appear positive for the autophagy protein ATG9A. Additional experiments in mice using a pharmacological activator of the HIF pathway support this link further, opening up potential therapeutic applications in certain autoimmune conditions or B cell malignancies.A powerful example of how researching rare genetic variants can provide much wider insights was published recently in a multi-disciplinary, Cambridge-led study of childbirth pain. Functional proteomics identifies part of the machinery sequestered at this viral RNA-induced compartment, while the cellular impact of disease-causing mutations in optineurin are also described.With key roles in normal cellular homeostasis and a range of diseases, autophagy is mediated by autophagosomes. An imposing copper-roofed building at Mill Hill was designed by,In 2003, as part of their Forward Investment Strategy, the MRC announced plans to consider moving NIMR from its current location to a university/medical school site, to enhance its ability "to translate its biomedical research into practical health outcomes. The CIMR has reopened for research on Monday June 15th, following detailed, University-approved protocols to protect our staff and students, who are the heart of our institution. We are creating a unified UKRI website that brings together the existing research council, Innovate UK and Research England websites. The MRC BNDU's collective goal is to understand and exploit the moment-to-moment interactions between nerve cells that are critical for brain functions, with a special focus on the brain circuits underlying movement and memory. The Unit’s vision is to lead scientific research to save lives and improve health across the developing world. Our institutes provide a stimulating and thriving research and learning environment.Our cutting-edge clinical and scientific research facilities and infrastructure underpin this. Our research contributes to understanding the molecular mechanisms of a … The Unit is developing a blood test for prion protein and has two programmes to develop novel therapies. The Unit will adopt a multidisciplinary approach to address major public health issues of relevance to the UK and global health agenda, drawing upon disciplines that extend beyond the conventional realms of epidemiology, to enhance causal and translational epidemiology.The MRC Lifecourse Epidemiology Unit at the University of Southampton (MRC LEU) at the University of Southampton aims to elucidate important, preventable causes of common chronic disorders and their complications.
The research carried out spans the spectrum from basic to translational science including developing new treatments for depression, improving hearing through cochlear implants and helping children to overcome memory problems.The MRC Centre for Drug Safety Science seeks to improve understanding of the toxicology of clinically important adverse drug reactions (ADRs).